From MSDWFP:
Mississippi’s spring squirrel season opens May 15 and closes June 1. Many of Mississippi’s open public lands and Wildlife Management Areas across the state offer squirrel hunting opportunities.

Hunters generally should look for areas with mature, hardwood forest cover for the best squirrel hunting experience. Anyone planning to hunt public land should read the regulations before they hunt. Some areas can have season dates and rules that differ from general statewide regulations.